It's me!

André Figueiredo Rendeiro
Postdoctoral Associate
Institute for Computational Biomedicine
Englander Institute for Precision Medicine
Weill Cornell Medicine

Address:
Weill Cornell Medicine
Greenberg Center
1305 York Ave
,
10021 New York, USA

Orcid ID:
0000-0001-9362-5373
Google Scholar:
André Figueiredo Rendeiro

Public Key:
PGP public key

Curriculum Vitae

Download my CV in PDF format

I am a Postdoctoral Associate in Computational Biomedicine at the Institute for Computational Biomedicine of Weill Cornell Medical College and the Englander Institute for Precision Medicine in the lab of Olivier Elemento.

I am currently developing computational methodologies to understand the spatial organization of tissue and the interplay between cancer cells, immune system and structural cell types, and how that can be applied for the development of novel therapeutical options or disease management. I develop and sometimes contribute to open source software. Check out my GitHub profile to see my tools and project contributions.

I did my PhD at the CeMM - Research Center for Molecular Medicine of the Austrian Academy of Sciences in the lab of Christoph Bock where I applied computational methods to high-dimentional molecular biology datasets of primary patient data in an effort to produce novel ways to monitor disease progression, predict risk and stratify patients and develop novel therapeutical avenues.

Research highlights

Spatial and temporally resolved COVID-19 pathology and immunology:
  1. Rendeiro*, Ravichandran*, et al, Nature, 2021
  2. Rendeiro et al, Life Science Alliance, 2020
Epigenetics for personalized medicine in cancer:
  1. Rendeiro*, Krausgruber*, et al, Nature Communications, 2020
  2. Schmidl*, Vladimer*, Rendeiro*, Schnabl*, et al, Nature Chemical Biology, 2019
  3. Rendeiro*, Schmidl*, Strefford*, et al, Nature Communications, 2016
Technology development:
  1. scifi-RNA-seq: Datlinger*, Rendeiro*, et al, bioRxiv, 2019
  2. ChIP-STARR-seq: Barakat*, Halbritter*, et al, Cell Stem Cell, 2018
  3. CROP-seq: Datlinger, et al, Nature Methods, 2017
  4. ChIPmentation: Schmidl*, Rendeiro*, et al, Nature Methods, 2015

Support

I am supported by a National Cancer Institute T32 grant for Molecular and Translational Oncology Research (T32CA203702) awarded to Weill Cornell Medical College.


Publications and associated resources

* equal contributions

All peer reviewed publications

  1. André F. Rendeiro*, Hiranmayi Ravichandran*, Yaron Bram, Vasuretha Chandar, Junbum Kim, Cem Meydan, Jiwoon Park, Jonathan Foox, Tyler Hether, Sarah Warren, Youngmi Kim, Jason Reeves, Steven Salvatore, Christopher E. Mason, Eric C. Swanson, Alain C. Borczuk, Olivier Elemento, Robert E. Schwartz.
    The spatial landscape of lung pathology during COVID-19 progression.
    Nature (2021). doi:10.1038/s41586-021-03475-6

  2. Sandra Schick, Sarah Grosche, Katharina Eva Kohl, Danica Drpic, Martin G. Jaeger, Nara C. Marella, Hana Imrichova, Jung-Ming G. Lin, Gerald Hofstätter, Michael Schuster, André F. Rendeiro, Anna Koren, Mark Petronczki, Christoph Bock, André C. Müller, Georg E. Winter & Stefan Kubicek.
    Acute BAF perturbation causes immediate changes in chromatin accessibility.
    Nature Genetics (2021). doi:10.1038/s41588-021-00777-3

  3. André F. Rendeiro, Joseph Casano, Charles Kyriakos Vorkas, Harjot Singh, Ayana Morales, Robert A DeSimone, Grant B Ellsworth, Rosemary Soave, Shashi N Kapadia, Kohta Saito, Christopher D Brown, JingMei Hsu, Christopher Kyriakides, Steven Chui, Luca Cappelli, Maria Teresa Cacciapuoti, Wayne Tam, Lorenzo Galluzzi, Paul D Simonson, Olivier Elemento, Mirella Salvatore, Giorgio Inghirami.
    Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression.
    Life Science Alliance (2020). doi:10.26508/lsa.202000955

  4. Alexander Swoboda, Robert Soukup, Oliver Eckel, Katharina Kinslechner, Bettina Wingelhofer, David Schörghofer, Christina Sternberg, Ha T T Pham, Maria Vallianou, Jaqueline Horvath, Dagmar Stoiber, Lukas Kenner, Lionel Larue, Valeria Poli, Friedrich Beermann, Takashi Yokota, Stefan Kubicek, Thomas Krausgruber, André F Rendeiro, Christoph Bock, Rainer Zenz, Boris Kovacic, Fritz Aberger, Markus Hengstschläger, Peter Petzelbauer, Mario Mikula, Richard Moriggl.
    STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway.
    Oncogene (2020). doi:10.1038/s41388-020-01584-6

  5. Thomas Krausgruber, Nikolaus Fortelny, Victoria Fife-Gernedl, Martin Senekowitsch, Linda C. Schuster, Alexander Lercher, Amelie Nemc, Christian Schmidl, André F. Rendeiro, Andreas Bergthaler, Christoph Bock.
    Structural cells are key regulators of organ-specific immune responses.
    Nature (2020). doi:10.1038/s41586-020-2424-4

  6. Rainer Hubmann, Susanne Schnabl, Mohammad Araghi, Christian Schmidl, André F. Rendeiro, Martin Hilgarth, Dita Demirtas, Farghaly Ali,Philipp B. Staber, Peter Valent, Christoph Zielinski, Ulrich Jäger, Medhat Shehata.
    Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL.
    Cells (2020). doi:10.3390/cells9061484

  7. Elizabeth C Rosser, Christopher J.M. Piper, Diana E Matei ,Paul A. Blair, André F. Rendeiro, Michael Orford, Dagmar G. Alber, Thomas Krausgruber, Diego Catalan, Nigel Klein, Jessica J. Manson, Ignat Drozdov, Christoph Bock, Lucy R Wedderburn, Simon Eaton, Claudia Mauri.
    Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells.
    Cell Metabolism (2020). doi:10.1016/j.cmet.2020.03.003

  8. André F. Rendeiro*, Thomas Krausgruber*, Nikolaus Fortelny, Fangwen Zhao, ThomasPenz, Matthias Farlik, Linda C. Schuster, Amelie Nemc, Szabolcs Tasnády, MariennRéti, Zoltán Mátrai, Donat Alpar, Csaba Bödör, Christian Schmidl, Christoph Bock.
    Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib drug response in CLL.
    Nature Communications (2020). doi:10.1038/s41467-019-14081-6

  9. Michael Delacher, Charles D Imbusch, Agnes Hotz-Wagenblatt, Jan-Philipp Mallm, Katharina Bauer, Malte Simon, Dania Riegel, André F. Rendeiro, Sebastian Bittner, Lieke Sanderink, Asmita Pant, Lisa Schmidleithner, Kathrin L Braband, Bernd Echtenachter, Alexander Fischer, Valentina Giunchiglia, Petra Hoffmann, Matthias Edinger, Christoph Bock, Michael Rehli, Benedikt Brors, Christian Schmidl, Markus Feuerer.
    Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF.
    Immunity (2020). doi:10.1016/j.immuni.2019.12.002

  10. Christopher JM Piper, Elizabeth C Rosser, Kristine Oleinika, Kiran Nistala, Thomas Krausgruber, André F. Rendeiro, Aggelos Banos, Ignat Drozdov, Matteo Villa, Scott Thomson, Georgina Xanthou, Christoph Bock, Brigitta Stockinger, Claudia Mauri.
    Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells.
    Cell Reports. (2019) doi:10.1016/j.celrep.2019.10.018

  11. Florian Puhm, Taras Afonyushkin, Ulrike Resch, Georg Obermayer, Manfred Rohde, Thomas Penz, Michael Schuster, Gabriel Wagner, André F. Rendeiro, Imene Melki, Christoph Kaun, Johann Wojta, Christoph Bock, Bernd Jilma, Nigel Mackman, Eric Boilard, Christoph J Binder.
    Mitochondria are a subset of extracellular vesicles released by activated monocytes and induce type I IFN and TNF responses in endothelial cells.
    Circulation Research. (2019) doi:10.1161/CIRCRESAHA.118.314601

  12. Sandra Schick, André F. Rendeiro, Kathrin Runggatscher, Anna Ringler, Bernd Boidol, Melanie Hinkel, Peter Májek, Loan Vulliard, Thomas Penz, Katja Parapatics, Christian Schmidl, Jörg Menche, Guido Boehmelt, Mark Petronczki, André C. Müller, Christoph Bock, Stefan Kubicek.
    Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers.
    Nature Genetics (2019). doi:10.1038/s41588-019-0477-9

  13. Sara Sdelci, André F. Rendeiro, Philipp Rathert, Wanhui You, Jung-Ming G. Lin, Anna Ringler, Gerald Hofstätter, Herwig P. Moll, Bettina Gürtl, Matthias Farlik, Sandra Schick, Freya Klepsch, Matthew Oldach, Pisanu Buphamalai, Fiorella Schischlik, Peter Májek, Katja Parapatics, Christian Schmidl, Michael Schuster, Thomas Penz, Dennis L. Buckley, Otto Hudecz, Richard Imre, Shuang-Yan Wang, Hans Michael Maric, Robert Kralovics, Keiryn L. Bennett, Andre C. Müller, Karl Mechtler, Jörg Menche, James E. Bradner, Georg E. Winter, Kristaps Klavins, Emilio Casanova, Christoph Bock, Johannes Zuber & Stefan Kubicek.
    MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.
    Nature Genetics (2019). doi:10.1038/s41588-019-0413-z

  14. Christian Schmidl*, Gregory I Vladimer*, André F. Rendeiro*, Susanne Schnabl*,Thomas Krausgruber, Christina Taubert, Nikolaus Krall, Tea Pemovska, MohammadAraghi, Berend Snijder, Rainer Hubmann, Anna Ringler, Kathrin Runggatscher,Dita Demirtas, Oscar Lopez de la Fuente, Martin Hilgarth, Cathrin Skrabs, Edit Porpaczy, Michaela Gruber, Gregor Hoermann, Stefan Kubicek, Philipp B Staber, Medhat Shehata, Giulio Superti-Furga, Ulrich Jäger, Christoph Bock.
    Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL.
    Nature Chemical Biology (2019). doi:10.1038/s41589-018-0205-2

  15. Tahsin Stefan Barakat*, Florian Halbritter*, Man Zhang, André F. Rendeiro, Christoph Bock, Ian Chambers.
    Functional dissection of the enhancer repertoire in human embryonic stem cells.
    Cell Stem Cell. (2018) doi:10.1016/j.stem.2018.06.014

  16. Paul Datlinger, André F Rendeiro*, Christian Schmidl*, Thomas Krausgruber, Peter Traxler, Johanna Klughammer, Linda C Schuster, Amelie Kuchler, Donat Alpar, Christoph Bock.
    Pooled CRISPR screening with single-cell transcriptome readout.
    Nature Methods. (2017) doi:10.1038/nmeth.4177

  17. Roman A Romanov, Amit Zeisel, Joanne Bakker, Fatima Girach, Arash Hellysaz, Raju Tomer, Alán Alpár, Jan Mulder, Frédéric Clotman, Erik Keimpema, Brian Hsueh, Ailey K Crow, Henrik Martens, Christian Schwindling, Daniela Calvigioni, Jaideep S Bains, Zoltán Máté, Gábor Szabó, Yuchio Yanagawa, Ming-Dong Zhang, Andre Rendeiro, Matthias Farlik, Mathias Uhlén, Peer Wulff, Christoph Bock, Christian Broberger, Karl Deisseroth, Tomas Hökfelt, Sten Linnarsson, Tamas L Horvath & Tibor Harkany.
    Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.
    Nature Neuroscience (2017). doi:10.1038/nn.4462

  18. Clara Jana-Lui Busch, Tim Hendrikx, David Weismann, Sven Jäckel, Sofie M. A. Walenbergh, André F. Rendeiro, Juliane Weißer, Florian Puhm, Anastasiya Hladik, Laura Göderle, Nikolina Papac-Milicevic, Gerald Haas, Vincent Millischer, Saravanan Subramaniam, Sylvia Knapp, Keiryn L. Bennett, Christoph Bock, Christoph Reinhardt, Ronit Shiri-Sverdlov, Christoph J. Binder.
    Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice.
    Hepatology (2017). doi:10.1002/hep.28970

  19. André F Rendeiro*, Christian Schmidl*, Jonathan C. Strefford*, Renata Walewska, Zadie Davis, Matthias Farlik, David Oscier, Christoph Bock.
    Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks.
    Nature Communications (2016). doi:10.1038/ncomms11938

  20. Christian Schmidl*, André F Rendeiro*, Nathan C Sheffield, Christoph Bock.
    ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors.
    Nature Methods (2015). doi:10.1038/nmeth.3542

  21. Michaela Schwaiger, Anna Schönauer, André F Rendeiro, Carina Pribitzer, Alexandra Schauer, Anna F Gilles, Johannes B Schinko, Eduard Renfer, David Fredman, Ulrich Technau.
    Evolutionary conservation of the eumetazoan gene regulatory landscape.
    Genome Research (2014). doi:10.1101/gr.162529.113

Preprints

  1. Nathan C. Sheffield, Michał Stolarczyk, Vincent P. Reuter, André F. Rendeiro.
    Linking big biomedical datasets to modular analysis with Portable Encapsulated Projects.
    bioRxiv (2020). doi:10.1101/2020.10.08.331322

  2. Paul Datlinger*, André F. Rendeiro*, Thorina Boenke, Thomas Krausgruber, Daniele Barreca, Christoph Bock.
    Ultra-high throughput single-cell RNA sequencing by combinatorial fluidic indexing.
    bioRxiv (2019). doi:10.1101/2019.12.17.879304

  3. André F Rendeiro, Pavla Navratilova, Eric Thompson.
    Chromatin preparation for ChIP-seq in Oikopleura dioica.
    Figshare (2014). doi:10.6084/m9.figshare.884562